Anti-tuberculosis activity of oleanolic and ursolic acid isolated from the dichloromethane extract of leaves from Duroia macrophylla

Introduction Tuberculosis a major cause of death worldwide, is an infectious disease caused by Mycobacterium tuberculosis. An increase in drug-resistant tuberculosis cases and the emergence of additional resistant strains and coinfections with HIV has stimulated the search for and development of new anti-TB drugs [1]. The wide variety of natural products chemical structures plays a major role on the development of new antimycobacterial drugs generations. Duroia macrophylla is an endemic plant of the Amazon Forest [2]. To the best of our knowledge, no chemical or biological investigations other than ours [3,4] have been carried out on this species as of yet. Hence this work aims to evaluate the antimycobacterial activity of their extracts and isolate and identify the substances present in D. macrophylla active extracts.